{"id":760,"date":"2020-05-02T13:28:48","date_gmt":"2020-05-02T07:58:48","guid":{"rendered":"http:\/\/www.potentialloops.org\/?p=760"},"modified":"2020-05-02T13:28:49","modified_gmt":"2020-05-02T07:58:49","slug":"scientists-regenerate-neurons-in-mice-with-spinal-cord-injury-and-optic-nerve-damage","status":"publish","type":"post","link":"https:\/\/www.potentialloops.org\/?p=760","title":{"rendered":"Scientists regenerate neurons in mice with spinal cord injury and optic nerve damage"},"content":{"rendered":"\n

Date: April 30, 2020 <\/p>\n\n\n\n

Source 1: Temple University Health System <\/p>\n\n\n\n

Source 2: www.sciencedaily.com<\/p>\n\n\n\n

Summary: Each year thousands of patients face life-long losses in sensation and motor function from spinal cord injury and related conditions in which axons are badly damaged or severed. New research in mice shows, however, that gains in functional recovery from these injuries may be possible, thanks to a molecule known as Lin28, which regulates cell growth. <\/p>\n\n\n\n

Like power lines in an electrical grid, long \nwiry projections that grow outward from neurons — structures known as \naxons — form interconnected communication networks that run from the \nbrain to all parts of the body. But unlike an outage in a power line, \nwhich can be fixed, a break in an axon is permanent. Each year thousands\n of patients confront this reality, facing life-long losses in sensation\n and motor function from spinal cord injury and related conditions in \nwhich axons are badly damaged or severed.<\/p>\n\n\n\n

New research by scientists at the Lewis Katz School of Medicine \nTemple University (LKSOM) shows, however, that gains in functional \nrecovery from these injuries may be possible, thanks to a molecule known\n as Lin28, which regulates cell growth. In a study published online in \nthe journal Molecular Therapy<\/em>, the Temple researchers describe \nthe ability of Lin28 — when expressed above its usual levels — to fuel\n axon regrowth in mice with spinal cord injury or optic nerve injury, \nenabling repair of the body’s communication grid.<\/p>\n\n\n\n

“Our findings show that Lin28 is a major regulator of axon \nregeneration and a promising therapeutic target for central nervous \nsystem injuries,” explained Shuxin Li, MD, PhD, Professor of Anatomy and\n Cell Biology and in the Shriners Hospitals Pediatric Research Center at\n the Lewis Katz School of Medicine at Temple University and senior \ninvestigator on the new study. The research is the first to demonstrate \nthe regenerative ability of Lin28 upregulation in the injured spinal \ncord of animals.<\/p>\n\n\n\n

“We became interested in Lin28 as a target for neuron regeneration \nbecause it acts as a gatekeeper of stem cell activity,” said Dr. Li. “It\n controls the switch that maintains stem cells or allows them to \ndifferentiate and potentially contribute to activities such as axon \nregeneration.”<\/p>\n\n\n\n

To explore the effects of Lin28 on axon regrowth, Dr. Li and \ncolleagues developed a mouse model in which animals expressed extra \nLin28 in some of their tissues. When full-grown, the animals were \ndivided into groups that sustained spinal cord injury or injury to the \noptic nerve tracts that connect to the retina in the eye.<\/p>\n\n\n\n

Another set of adult mice, with normal Lin28 expression and similar \ninjuries, were given injections of a viral vector (a type of carrier) \nfor Lin28 to examine the molecule’s direct effects on tissue repair.<\/p>\n\n\n\n

Extra Lin28 stimulated long-distance axon regeneration in all \ninstances, though the most dramatic effects were observed following \npost-injury injection of Lin28. In mice with spinal cord injury, Lin28 \ninjection resulted in the growth of axons to more than three millimeters\n beyond the area of axon damage, while in animals with optic nerve \ninjury, axons regrew the entire length of the optic nerve tract. \nEvaluation of walking and sensory abilities after Lin28 treatment \nrevealed significant improvements in coordination and sensation.<\/p>\n\n\n\n

“We observed a lot of axon regrowth, which could be very significant \nclinically, since there currently are no regenerative treatments for \nspinal cord injury or optic nerve injury,” Dr. Li explained.<\/p>\n\n\n\n

One of his goals in the near-term is to identify a safe and effective\n means of getting Lin28 to injured tissues in human patients. To do so, \nhis team of researchers will need to develop a vector, or carrier system\n for Lin28, that can be injected systemically and then hone in on \ninjured axons to deliver the therapy directly to multiple populations of\n damaged neurons.<\/p>\n\n\n\n

Dr. Li further wants to decipher the molecular details of the Lin28 \nsignaling pathway. “Lin28 associates closely with other growth signaling\n molecules, and we suspect it uses multiple pathways to regulate cell \ngrowth,” he explained. These other molecules could potentially be \npackaged along with Lin28 to aid neuron repair.<\/p>\n\n\n\n

Other researchers contributing to the work include Fatima M. Nathan, \nYosuke Ohtake, Shuo Wang, Xinpei Jiang, Armin Sami, and Hua Guo, \nShriners Hospitals Pediatric Research Center and the Department of \nAnatomy and Cell Biology at the Lewis Katz School of Medicine; and \nFeng-Quan Zhou, Department of Orthopaedic Surgery and The Solomon H. \nSnyder Department of Neuroscience at Johns Hopkins University School of \nMedicine, Baltimore.<\/p>\n\n\n\n

The research was supported in part by National Institute of Health \ngrants R01NS105961, 1R01NS079432, and 1R01EY024575 and by funding from \nShriners Research Foundation.<\/p>\n\n\n\n

\n\n\n\n

Story Source:<\/strong><\/p>\n\n\n\n

Materials<\/a> provided by Temple University Health System<\/strong><\/a>. Note: Content may be edited for style and length.<\/em><\/p>\n\n\n\n

\n\n\n\n

Journal Reference<\/strong>:<\/p>\n\n\n\n

  1. Fatima M. Nathan, Yosuke Ohtake, Shuo Wang, Xinpei Jiang, Armin Sami, Hua Guo, Feng-Quan Zhou, Shuxin Li. Upregulating Lin28a Promotes Axon Regeneration in Adult Mice with Optic Nerve and Spinal Cord Injury<\/strong>. Molecular Therapy<\/em>, 2020; DOI: 10.1016\/j.ymthe.2020.04.010<\/a>\n<\/li><\/ol>\n\n\n\n

    Summary: Each year thousands of patients face life-long losses in sensation and motor function from spinal cord injury and related conditions in which axons are badly damaged or severed. New research in mice shows, however, that gains in functional recovery from these injuries may be possible, thanks to a molecule known as Lin28, which regulates cell growth. <\/p>\n","protected":false},"excerpt":{"rendered":"

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