{"id":793,"date":"2020-05-16T10:44:32","date_gmt":"2020-05-16T05:14:32","guid":{"rendered":"http:\/\/www.potentialloops.org\/?p=793"},"modified":"2020-05-16T10:44:34","modified_gmt":"2020-05-16T05:14:34","slug":"further-evidence-does-not-support-hydroxychloroquine-for-patients-with-covid-19","status":"publish","type":"post","link":"https:\/\/www.potentialloops.org\/?p=793","title":{"rendered":"Further evidence does not support hydroxychloroquine for patients with COVID-19"},"content":{"rendered":"\n

Adverse events were more common in those receiving the drug<\/p>\n\n\n\n

Date: May 15, 2020 <\/p>\n\n\n\n

Source 1: BMJ <\/p>\n\n\n\n

Source 2: www.sciencedaily.com<\/a><\/p>\n\n\n\n

Summary: The anti-inflammatory drug hydroxychloroquine does not significantly reduce admission to intensive care or death in patients hospitalized with pneumonia due to COVID-19, finds a study from France. And a randomized clinical trial from China shows that hospitalized patients with mild to moderate persistent covid-19 who received hydroxychloroquine did not clear the virus more quickly than those receiving standard care. <\/p>\n\n\n\n

The anti-inflammatory drug hydroxychloroquine\n does not significantly reduce admission to intensive care or death in \npatients hospitalised with pneumonia due to covid-19, finds a study from\n France published by The BMJ<\/em> today.<\/p>\n\n\n\n

A randomised clinical trial from China also published today shows \nthat hospitalised patients with mild to moderate persistent covid-19 who\n received hydroxychloroquine did not clear the virus more quickly than \nthose receiving standard care. Adverse events were higher in those who \nreceived hydroxychloroquine.<\/p>\n\n\n\n

Taken together, the results do not support routine use of hydroxychloroquine for patients with covid-19.<\/p>\n\n\n\n

Hydroxychloroquine can reduce inflammation, pain, and swelling, and \nis widely used to treat rheumatic diseases. It is also used as an \nanti-malarial drug. Lab tests showed promising results, but accumulating\n trial and observational evidence has called into question whether there\n are any meaningful clinical benefits for patients with covid-19.<\/p>\n\n\n\n

Despite this, hydroxychloroquine has already been included in Chinese\n guidelines on how best to manage the disease, and the US Food and Drug \nAdministration (FDA) issued an emergency use authorization to allow the \ndrug to be provided to certain hospitalized patients. The FDA has since \nwarned against use outside clinical trials or hospital settings due to \nthe risk of heart rhythm problems.<\/p>\n\n\n\n

In the first study, researchers in France assessed the effectiveness \nand safety of hydroxychloroquine compared with standard care in adults \nadmitted to hospital with pneumonia due to covid-19 who needed oxygen.<\/p>\n\n\n\n

Of 181 patients, 84 received hydroxychloroquine within 48 hours of admission and 97 did not (control group).<\/p>\n\n\n\n

They found no meaningful differences between the groups for transfer \nto intensive care, death within 7 days, or developing acute respiratory \ndistress syndrome within 10 days.<\/p>\n\n\n\n

The researchers say that caution is needed in the interpretation of \ntheir results, but that their findings do not support the use of \nhydroxychloroquine in patients hospitalised with covid-19 pneumonia.<\/p>\n\n\n\n

In the second study, researchers in China assessed the effectiveness \nand safety of hydroxychloroquine compared with standard care in 150 \nadults hospitalised with mainly mild or moderate covid-19.<\/p>\n\n\n\n

Patients were randomly split into two groups. Half received \nhydroxychloroquine in addition to standard care and the others received \nstandard care only (control group).<\/p>\n\n\n\n

By day 28, tests revealed similar rates of covid-19 in the two groups\n but adverse events were more common in those who received \nhydroxychloroquine. Symptom alleviation and time to relief of symptoms \nalso did not differ meaningfully between the two groups.<\/p>\n\n\n\n

While further work is needed to confirm these results, the authors \nsay that their findings do not support the use of hydroxychloroquine to \ntreat patients with persistent mild to moderate covid-19.<\/p>\n\n\n\n

\n\n\n\n

Story Source:<\/strong><\/p>\n\n\n\n

Materials<\/a> provided by BMJ<\/strong><\/a>. Note: Content may be edited for style and length.<\/em><\/p>\n\n\n\n

www.sciencedaily.com<\/a><\/p>\n\n\n\n

\n\n\n\n

Journal References<\/strong>:<\/p>\n\n\n\n

  1. Matthieu Mah\u00e9vas, Viet-Thi Tran, Mathilde Roumier, Am\u00e9lie Chabrol, \nRomain Paule, Constance Guillaud, Elena Fois, Raphael Lepeule, Tali-Anne\n Szwebel, Fran\u00e7ois-Xavier Lescure, Fr\u00e9d\u00e9ric Schlemmer, Marie Matignon, \nMehdi Khellaf, Etienne Crickx, Benjamin Terrier, Caroline Morbieu, Paul \nLegendre, Julien Dang, Yoland Schoindre, Jean-Michel Pawlotsky, Marc \nMichel, Elodie Perrodeau, Nicolas Carlier, Nicolas Roche, Victoire de \nLastours, Cl\u00e9ment Ourghanlian, Solen Kerneis, Philippe M\u00e9nager, Luc \nMouthon, Etienne Audureau, Philippe Ravaud, Bertrand Godeau, S\u00e9bastien \nGallien, Nathalie Costedoat-Chalumeau. Clinical efficacy of \nhydroxychloroquine in patients with covid-19 pneumonia who require \noxygen: observational comparative study using routine care data<\/strong>. BMJ<\/em>, 2020; m1844 DOI: 10.1136\/bmj.m1844<\/a>\n<\/li>
  2. Wei Tang, Zhujun Cao, Mingfeng Han, Zhengyan Wang, Junwen Chen, \nWenjin Sun, Yaojie Wu, Wei Xiao, Shengyong Liu, Erzhen Chen, Wei Chen, \nXiongbiao Wang, Jiuyong Yang, Jun Lin, Qingxia Zhao, Youqin Yan, Zhibin \nXie, Dan Li, Yaofeng Yang, Leshan Liu, Jieming Qu, Guang Ning, Guochao \nShi, Qing Xie. Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial<\/strong>. BMJ<\/em>, 2020; m1849 DOI: 10.1136\/bmj.m1849<\/a>\n<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"

    Adverse events were more common in those receiving the drug Date: May 15, 2020 Source 1: BMJ Source 2: www.sciencedaily.com Summary: The anti-inflammatory drug hydroxychloroquine does not significantly reduce admission to intensive care or death in patients hospitalized with pneumonia due to COVID-19, finds a study from France. And a randomized clinical trial from China […]<\/p>\n","protected":false},"author":1,"featured_media":794,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[35],"tags":[145,147,146,148,144,75,40,149],"class_list":["post-793","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-coronavirus","tag-anti-inflammatory","tag-clinical-trial","tag-evidence","tag-hospitalised","tag-hydroxychloroquine","tag-patients","tag-research","tag-syndrome"],"aioseo_notices":[],"yoast_head":"\nFurther evidence does not support hydroxychloroquine for patients with COVID-19 -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.potentialloops.org\/?p=793\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Further evidence does not support hydroxychloroquine for patients with COVID-19 -\" \/>\n<meta property=\"og:description\" content=\"Adverse events were more common in those receiving the drug Date: May 15, 2020 Source 1: BMJ Source 2: www.sciencedaily.com Summary: The anti-inflammatory drug hydroxychloroquine does not significantly reduce admission to intensive care or death in patients hospitalized with pneumonia due to COVID-19, finds a study from France. 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